Detail Low Activity of Manganese Superoxide Dismutase (MnSOD) in Blood of Lung Cancer Patients with Smoking History : Relationship to Oxidative Stress (di dalam Asian Pacific Journal of Cancer Prevention, Vol12) Bibliografi Author: Margaret, Ayly ; Syahruddin, Elisna ; Wanandi, Septelia Inawati Topik: MnSOD activity - lung cancer - lipid peroxidation - carbonyl - smoking - Indonesia Bahasa: (EN )    ISBN: 3049-3053     Penerbit: Asian Pacific Organization for Cancer Prevention     Tempat Terbit: Gyeonggi    Tahun Terbit: 2011     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: artikel APJCP yang dipublished.pdf (359.99KB; 2 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract Lung cancer is the primary cause of cancer death in the world. Although it is well established that tobacco smoke causes lung cancer, not all smokers develop lung cancer. Manganese superoxide dismutase (MnSOD), a major determinant of antioxidants in matrix mitochondria, plays a pivotal role in eliminating anion superoxide free radical generated from the tobacco smoke. The aim of this study was to analyze the enzyme activity of MnSOD in blood of lung cancer patients with a smoking history in relationship to oxidative stress. Samples were taken from leukocyte cells of 20 lung cancer patients in Persahabatan Hospital Jakarta. Control groups included 50 healthy smokers and 50 non smokers, all aged over 40 years. The MnSOD activity determined biochemically based on the inhibition of xanthin oxidase, of lung cancer patients was lower than the control group’s (p<0.001). Plasma MDA levels, determined by reaction with thiobarbituric acid (TBA), were not significantly different (p=0.479), whereas plasma carbonyl levels were elevated (p=0.003). Free radical production in lung cancer patients thus appeared high. Smoker controls also tended to exhibit lower MnSOD and higher carbonyl radicals than their non-smoking counterparts. Continue cigarette smoke exposure may increase production of ROS and bring about a reduction of MnSOD, which could play a role in lunfg cancer development. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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