Lysine requirement in parenterally fed postsurgical human neonates  

Oleh:

[s.n]

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 91 no. 04 (Apr. 2010), page 958-965.
Topik: HEALTH AND NUTRITION; energy and protein metabolism

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

ackground: The lysine requirement of human neonates receiving parenteral nutrition (PN) has not been determined experimentally. Objective: The objective was to determine the parenteral lysine requirement for human neonates by using the minimally invasive indicator amino acid oxidation technique with L-[1-13C] phenylalanine as the indicator amino acid. Design: Eleven postsurgical neonates were randomly assigned to 15 lysine intakes ranging from 50 to 260 mg · kg–1 · d–1. Breath and urine samples were collected at baseline and at plateau for 13CO2 (F13CO2) and amino acid enrichment, respectively. The mean lysine requirement was determined by applying a 2-phase linear regression crossover analysis to the measured rates of F13CO2 release and L-[1-13C]phenylalanine oxidation. Results: The mean parenteral lysine requirement determined by F13CO2 release oxidation was 104.9 mg · kg–1 · d–1 (upper and lower CIs: 120.6 and 89.1 mg · kg–1 · d–1, respectively). The mean lysine parenteral requirement determined by phenylalanine oxidation was 117.6 mg · kg–1 · d–1 (upper and lower CIs: 157.5 and 77.6 mg · kg–1 · d–1, respectively). Graded intakes of lysine had no effect on phenylalanine flux.Conclusion: We recommend a mean lysine requirement for the postsurgical PN-fed neonate of 104.9 mg · kg–1 · d–1, which is 32–43% of the lysine concentration presently found in commercial PN solutions (246–330 mg · kg–1 · d–1).

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali