Induction of insulin resistance by phosphatidylinositol-3-kinase inhibitor in porcine granulosa cells  

Oleh:

Miaoe, Yan ; Jing, Wang ; Xiaoke, Wu ; Lihui, Hou ; Haixue, Kuang ; Yongyan, Wang

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 06 (Dec. 2009), page 2119-2121.

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Insulin resistance on porcine granulosa cells was induced by wortmannin, the phosphatidylinositol-3-kinase inhibitor, and insulin signaling key molecules were investigated including glut4 and mitogen-activated protein kinase. Granulosa insulin resistance decreased glut4 expression but increased mitogen-activated protein kinase, indicating the cross talk between the metabolic and mitogenic pathways of insulin signaling in the ovary.

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