Dietary predictors of the insulin-like growth factor system in adolescent females: results from the Dietary Intervention Study in Children (DISC)  

Oleh:

Kerver, Jean M ; Gardiner, Joseph C

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 91 no. 03 (Mar. 2010), page 643-650.
Topik: HEALTH AND NUTRITION; Growth; development; and pediatrics

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: The insulin-like growth factor (IGF) system is associated with the adult diet and chronic disease. Childhood diet may influence chronic disease through its effect on the IGF system; however, there is limited information describing the dietary predictors of the IGF system in adolescents. Objective: We examined associations between dietary food intake [fat, protein (animal and vegetable), carbohydrate, lactose, dietary fiber, calcium, zinc, and sodium] and serum IGF-I, IGF binding protein 1 (IGFBP-1), IGF binding protein 3 (IGFBP-3), and the IGF-I:IGFBP-3 molar ratio in adolescent females. Design: One hundred fifty-nine adolescent females in the Dietary Intervention Study in Children (age range: 14–18 y; 0.2–6.3 y postmenarche) were included. The dietary intake was assessed via three 24-h dietary recalls. IGF-related biomarkers were determined by using radioimmunoassays. Associations between dietary intakes and biomarkers were assessed with Pearson's correlations and multivariable linear regression. Dietary intakes and biomarkers were logarithmically transformed; thus, ß coefficients represented percentages. Results: In analyses adjusted for energy, age, and time since menarche, significant correlations (P < 0.05) were as follows: IGF-I with total protein, lactose, calcium, and sodium; IGFBP-3 with total fat (inverse), lactose, fiber, and calcium; IGF-I/IGFBP-3 with lactose and calcium; and IGFBP-1 with vegetable protein. In multivariable analyses, significant predictors of IGF-I were energy (ß = 0.14, P < 0.05) and calcium (ß = 0.14, P < 0.01), the significant predictor of IGFBP-3 was calcium (ß = 0.07, P < 0.05), and significant predictors of IGFBP-1 were vegetable protein (ß = 0.49, P < 0.05) and body mass index–for-age percentile (ß = –0.01, P < 0.001). Conclusion: This study provides evidence that dietary intake affects IGF-related biomarkers—particularly elevated calcium with IGF-I and IGFBP-3 and elevated vegetable protein with IGFBP-1—and, to our knowledge, is novel in reporting these associations in adolescent females.

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