Effects of estradiol supplementation during the luteal phase of in vitro fertilization cycles: a meta-analysis  

Oleh:

Byung, Chul Jee ; Chang, Suk Suh

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 02 (Jan. 2010), page 428-436.
Topik: OBSTETRI GINEKOLOGI; Estradiol; luteal phase; in vitro fertilization; GnRH agonist; GnRH antagonist

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To clarify whether adding E2 to standard luteal P supplementation is beneficial both in GnRH agonist and antagonist IVF cycles. Design: Meta-analysis of nine randomized controlled trials. Setting: University hospital center for reproductive medicine and IVF. Intervention(s): None. Main Outcome Measure(s): Clinical pregnancy rate (PR) per patient, clinical PR per embryo transfer (ET), implantation rate, ongoing PR per patient, clinical abortion rate, and ectopic PR. Result(s): There were no statistically significant differences between E2+P versus P-only group regarding overall IVF outcomes. From seven studies including GnRH agonist cycles, no statistical significant differences were found between the two groups in clinical PR per patient (relative risk [RR] 1.32, 95% confidence interval [CI] 0.79–2.19), clinical PR per ET (RR 1.83, 95% CI 0.96–3.49), implantation rate (RR 1.20, 95% CI 0.34–4.21), ongoing PR per patient (RR 1.34, 95% CI 0.37–4.82), clinical abortion rate (RR 1.05, 95% CI 0.48–2.28), and ectopic PR (RR 0.53, 95% CI 0.07–4.10). Clinical PR per patient (RR 0.94, 95% CI 0.62–1.42) and ongoing PR per patient (RR 1.09, 95% CI 0.79–1.50) from three studies including GnRH antagonist cycles only were all similar between the two groups. Conclusion(s): The combined data presented in this meta-analysis suggest that the addition of E2 to P for luteal phase support does not improve IVF outcomes in GnRH agonist and antagonist cycles. However, the authors feel that there is an obvious need for further large-scale studies regarding GnRH antagonist cycles.

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