Uji Aktivitas Ekstrak Etanol 50% Umbi Keladi Tikus(Typhonium Flagelliforme (Lood) BI) Terhadap Sel Kanker Payudara MCF-7 in Vitro  

Oleh:

Widowati, Lucie ; Mudahar, Harfia

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Media Penelitian dan Pengembangan Kesehatan vol. 19 no. 01 (Mar. 2009), page 9-14.
Topik: Ethanol Extract 50% Of Keladi Tikus Root (Typhonium flagelliforme (Lood) BI); Breast Cancer; MCF-7 Cell; LCo
Fulltext: M45 Vol 19, No 1 Mar (2009) p9.PDF (409.95KB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: M45 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk
Perpustakaan FK Nomor Panggil: M32.K.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk

Isi artikel

Keladi tikus root (Typhonium flagelliforme (Lodd) BI) is one of plants that is used for cancer healing. The plant contents flavonoid, tannin, terpenoid and steroid. Flavonoid and terpenoid compound groups are known for anti cancer activities. The investigation is conducted to test cytotoxic effect of ethanol freedry extract of keladi tikus root (Typhonium flagelliforme (Lood)BI) against brest cancer cell MCF-7. Maceration extraction method used 50% ethanol solvent and vaporized until ethanol free dry extract of keladi tikus root was obtained. The test used 5 level of concentration, those were 50, 75, 100,125 and 150 flg/ml with 3 times iteration. DMSO was used as negative control and Cisplatin with concentration of 4, 6, 8, 19, 12 j.ig/ml were used as positive control. Test result showed ethanol free dry extract of keladi tikus root has value of LC50 = 89,15 and Cisplatin has value of LC50 = 7,84 j.ig/ml .Further investigation of advance sitotoxic test value LC50and value LCo against fraction of 50% ethanol extract is necessary to obtain active compound against brest cancer cell MCF-7.

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