Micromanaging Cancer  

Oleh:

Lieberman, Judy

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 15 (Oct. 2009), page 1500-1501.
Topik: Cancer

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The discovery of RNA interference triggered a "silent" revolution that overturned our understanding of how gene expression is regulated. The previous model was that gene expression was activated during transcription, the process of copying the DNA sequence into RNA, when transcription factor proteins bind to promoter sequences in DNA upstream of the gene's coding sequence. Now it is clear that an additional important mechanism of gene regulation occurs at the next stage of translating the messenger RNA (mRNA) into protein. Small, noncoding RNAs that have a stem loop structure, called microRNAs, regulate translation by binding to partially complementary sequences of about 22 bases in length in the untranslated region of the mRNA downstream from the coding sequence and interfere with or silence its translation into protein.

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