Rendering the Leukemia Cell Susceptible to Attack  

Oleh:

Sipkins, Dorothy A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 13 (Sep. 2009), page 1307-1309 .
Topik: Leukemia

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The cytokine interferon-{alpha} is thought to exert its antitumor effects through pleiotropic mechanisms, including the modulation of immune responses and the inhibition of angiogenesis.1 In addition, interferon-{alpha} inhibits growth and promotes apoptosis of many cell types. A recent study by Essers and colleagues2 provides new insight into the effects of interferon-{alpha} on hematopoietic stem cells, revealing its proliferative effects on this quiescent cell population. Their findings also suggest a potential therapeutic application of interferons in shifting dormant yet viable cancer cells into the cell cycle to increase their susceptibility to cytotoxic chemotherapy.

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