Soy allergy in infants and children with IgE-associated cow’s milk allergy  

Oleh:

Zeiger, Robert S. ; Sampson, Hugh A. ; Bock, S.Allan ; Burks, A. Wesley ; Harden, Kathleen

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 135 no. 05 (Nov. 1999), page 614-622.
Topik: CM ; Cow’s milk; CMA ; Cow’s milk allergy; DBPCFC ; Double-blind; placebo-controlled food challenge; EPH ; Extensively hydrolyzed protein hydrolysate; NCHS ; National Center for Health Statistics; SPT ; Skin prick test

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K.1999.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objectives: To determine the prevalence of soy allergy in IgE-associated cow’s milk allergy (CMA). Study design: Children <3.5 years with documented IgE-associated CMA (n = 93) were evaluated for soy allergy by double-blind, placebo-controlled food challenge, open challenge, or convincing previous history of an anaphylactic reaction to soy. Children tolerant to soy at entry received soy formula and were followed up for 1 year. Results: Of this IgE-associated CMA cohort (ages 3 to 41 months), 14% (95% CI = 7.7%-22.7%) were determined to have soy allergy, 12 definitely at entry and 1 possibly after 1 year of soy ingestion. The latter child experienced severe failure to thrive at enrollment and exhibited improved growth while receiving soy during follow-up but was diagnosed with eosinophilic esophagitis at study completion. Improved growth (P < .05) occurred in the non-soy-allergic cohort ingesting soy formula (579 ± 31 mL/d) during the year of follow-up. Conclusions: Soy allergy occurs in only a small minority of young children with IgE-associated CMA. As such, soy formula may provide a safe and growth-promoting alternative for the majority of children with IgE-associated CMA shown to be soy tolerant at the time of introduction of soy formula.

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