Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders  

Oleh:

Connolly, Anne M. ; Chez, Michael G. ; Pestronk, Alan ; Arnold, Susan T. ; Mehta, Shobhna ; Deuel, Ruthmary K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 135 no. 05 (Nov. 1999), page 607-613.
Topik: ANA ; Antinuclear antibody; ASD ; Autistic spectrum disorder; EEG ; Electroencephalogram; HC ; Healthy children; LKS ; Landau-Kleffner syndrome; LKSV ; Landau-Kleffner syndrome variant; NNI ; Non-neurologic illness; ONDs ; Other neurologic disorders; PBS ; Phosphate-buffered saline

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K.1999.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: Etiologically unexplained disorders of language and social development have often been reported to improve in patients treated with immune-modulating regimens. Here we determined the frequency of autoantibodies to brain among such children. Design: We collected sera from a cohort of children with (1) pure Landau-Kleffner syndrome (n = 2), (2) Landau-Kleffner syndrome variant (LKSV, n = 11), and (3) autistic spectrum disorder (ASD, n = 11). None had received immune-modulating treatment before the serum sample was obtained. Control sera (n = 71) were from 29 healthy children, 22 with non-neurologic illnesses (NNIs), and 20 children with other neurologic disorders (ONDs). We identified brain autoantibodies by immunostaining of human temporal cortex and antinuclear autoantibodies using commercially available kits. Results: IgG anti-brain autoantibodies were present in 45% of sera from children with LKSV, 27% with ASD, and 10% with ONDs compared with 2% from healthy children and control children with NNIs. IgM autoantibodies were present in 36% of sera from children with ASD, 9% with LKSV, and 15% with ONDs compared with 0% of control sera. Labeling studies identified one antigenic target to be endothelial cells. Antinuclear antibodies with titers =1:80 were more common in children with ASD and control children with ONDs. Conclusion: Children with LKSV and ASD have a greater frequency of serum antibodies to brain endothelial cells and to nuclei than children with NNIs or healthy children. The presence of these antibodies raises the possibility that autoimmunity plays a role in the pathogenesis of language and social developmental abnormalities in a subset of children with these disorders.

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