The Potential of ß-Carotene as Free Radical Scavenger: A Study of the Raise of Superoxide Production in Mitochondrial Lymphocyte  

Oleh:

Samsuria-Mutalib, Peni K. ; Kusmardi ; Tedjo, Aryo

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Kesehatan vol. 13 no. 1 (Jun. 2009), page 27.
Topik: Antioxidant; ß-carotene; Free Radical; Superoxide; Lymphocyte

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM75.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This is a study on carotenoid extracted from ‘Minyak Buah Merah' (Pandanus conoideus) in therapy simulation usinghigh dose of ß-carotene on two lymphocytes-that of a healthy subject and a leukemia patient. Superoxide productionin mithocondrial lymphocyte as a result of ß-carotene exposure was examined using a flow cytometer. The test findsthat superoxide (a specific mitochondrial free radical) increases easier and faster in leukemic lymphocytes than innormal lymphocytes. The results of the study support previous meta-analysis studies that high dosages of ß-caroteneand vitamin E supplements as antioxidant should be discouraged because it increases all-cause mortality.

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