The MDA and HSP70 concentration in preeclamptic patient placenta's.  

Oleh:

Santosa, Dewi Irawati Soeria ; Subakir, Sri Bekti ; Arleni

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Kesehatan vol. 12 no. 2 (Dec. 2008), page 92.
Topik: MDA; HSP70; Placenta; Preeclampsia; Stress Oxidative

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM75.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: Preeclampsia is a disease inpregnancy and characterized by hypertension and proteinuria. Preeclampsia and eclampsia are the most causes ofmaternal and fetal mortality and morbidity in Indonesia. Placental and systemic oxidative stress caused endothelial celldysfunction and injury. Placental oxidative stress also linked to fetal growth restriction. HSP70 is essential for cellularrecovery, survival and maintenance of homeostasis. The purpose of this study was to compare the MDA, a marker foroxidative stress and HSP70 production in placental of severe preeclampsia, mild preeclampsia and normotensivepregnant women. Method: Placenta were collected after delivery from normotensive pregnancies (N=10), severepreeclampsia (N=10) and mild preeclampsia (N=10). Placenta was cultured in RPMI and 20% FBS, and supernatantwere collected in day 3. MDA was measured using spectrophotometer and absorbance read in 530nm. HSP70 wasmeasured using enzyme-linked immunosorbent assay. Result and Discussion: The mean MDA concentration did notdiffer significantly between patients with severe preeclampsia (7.13+5.36 nmol/ml) and mild preeclampsia (4.82+2.47nmol/ml) when compared with normotensive pregnancies (4.57+2.4 nmol/ml). The mean HSP70 concentration in mildpreeclampsia is highest (10.15+12.39 nmo/ml) when compared with severe preeclampsia (3.78 +3.07 nmol/ml) andnormotensive pregnant women (3.76+4.65nmol/ml), but the difference was not significant. Although the difference wasnot significant, is indicates homeostasis response in mild preclampsia women is relative good. This response was abatedin severe preeclampstic women. Conclusion: Although MDA and HSP70 concentration did not differ significantlybetween groups, however the high HSP70 concentration is indicates homeostasis response relatively good in mildpreeclamptic women.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali