Vagal nerve stimulation for treatment of children with epilepsy  

Oleh:

Camfield, Peter R. ; Camfield, Carol S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 135 no. 05 (Nov. 1999), page 532-533.
Topik: Vagal nerve; epilepsy

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K.1999.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

In this issue Murphy et al outline the effectiveness of an implanted vagal nerve stimulator to reduce seizures in 60 children with intractable epilepsy. Over the 18 months after implantation, there was a reduction in seizure frequency of about 50%. The device was well tolerated, and only 5 children discontinued its use. The reader will note that most children in this study were teenagers, although the youngest was 3.6 years of age. We know little of the clinical profile of these children. In two thirds, the etiology of the epilepsy was unknown. In addition, it is not known whether the children were intellectually or neurologically normal, features often associated with intractable epilepsy in children. It seems improbable that stimulation of the vagus nerve would have an effect on epilepsy, and yet it does. The physiologic reason is unknown. The vagus nerve carries efferent parasympathetic instructions mainly to the gut but also to the heart, larynx, and other organs. Afferent messages are returned to the brain from a variety of viscera. When the vagus nerve is stimulated, the message is received in the medulla in the tractus solitarius and then projected widely through the nervous system.

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