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Increased incidence of cancer in patients with cartilage-hair hypoplasia
Oleh:
Makitie, Outi
;
Pukkala, Eero
;
Teppo, Lyly
;
Kaitila, Ilkka
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
The Journal of Pediatrics vol. 134 no. 3 (Mar. 1999)
,
page 315-318.
Topik:
CHH
;
Cartilage-hair hypoplasia
;
CI
;
Confidence interval
;
SIR
;
Standardized incidence ratio
Ketersediaan
Perpustakaan FK
Nomor Panggil:
J45.K
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Objective: Previous reports have suggested an increased risk of cancer among patients with cartilage-hair hypoplasia (CHH). This study was carried out to further evaluate this risk among patients with CHH and their first-degree relatives. Study design: One hundred twenty-two patients with CHH were identified through 2 countrywide epidemiologic surveys in 1974 and in 1986. Their parents and nonaffected siblings were identified through the Population Register Center. This cohort underwent follow-up for cancer incidence through the Finnish Cancer Registry to the end of 1995. Results: A statistically significant excess risk of cancer was seen among the patients with CHH (standardized incidence ratio 6.9, 95% confidence interval 2.3 to 16), which was mainly attributable to non-Hodgkin’s lymphoma (standardized incidence ratio 90, 95% confidence interval 18 to 264). In addition, a significant excess risk of basal cell carcinoma was seen (standardized incidence ratio 35, 95% confidence interval 7.2 to 102). The cancer incidence among the siblings or the parents did not differ from the average cancer incidence in the Finnish population. Conclusions: This study confirms an increased risk of cancer, especially non-Hodgkin’s lymphoma, probably attributable to defective immunity, among patients with CHH.
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