The leukotriene D4 -receptor antagonist zafirlukast attenuates exercise-induced bronchoconstriction in children  

Oleh:

Pearlman, David S. ; Ostrom, Nancy K. ; Bronsky, Edwin A. ; Bonuccelli, Catherine M. ; Hanby, Laura A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 134 no. 3 (Mar. 1999), page 273-279.
Topik: AUC ; Area under the time % change in FEV1 curve; FEV1; Forced expiratory volume in 1 second

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To determine the effects of zafirlukast on exercise-induced bronchoconstriction in children. Study design: Exercise challenges were done 4 hours after single oral doses of zafirlukast or placebo were administered in asthmatic children (6 to 14 years) treated with ß2 -agonists alone. Subjects randomized to treatment had a =20% decrease in forced expiratory volume in 1 second (FEV1 ) after a screening challenge. In a randomized, double-blind, 3-way, crossover design, group 1 (n = 20) received placebo and 5 and 20 mg zafirlukast, and group 2 (n = 19) received placebo and 10 and 40 mg zafirlukast. Maximal percentage fall in FEV1 , area under the curve, and time to recovery of FEV1 to within 5% of baseline after the challenge were compared with analysis of variance. Results: Mean values for maximal fall in FEV1 ranged from –8.7% ± 1.7% to –11.1% ± 1.9% after zafirlukast compared with –17.1% ± 1.8% and –16.3% ± 1.9% after placebo. Differences from placebo for fall in FEV1 and area under the curve were significant (P = .05) after 5, 20, and 40 mg zafirlukast and approached significance (P = .08) after 10 mg zafirlukast. After all zafirlukast doses, recovery times (means of 5 to 7 minutes) decreased significantly (P = .05) and by approximately half compared with placebo (11 and 14 minutes). Safety assessments did not differ among treatments. Conclusion: Four hours after dosing, zafirlukast attenuated exercise-induced bronchoconstriction in children.

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