Growth, nutritional status, body composition, and energy expenditure in prepubertal children with Alagille syndrome  

Oleh:

Wasserman, Dror ; Zemel, Babette S. ; Mulberg, Andrew E. ; John, Helen A. ; Emerick, Karan M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 135 no. 02 (Feb. 1999), page 172-177.
Topik: AGS ; Alagille syndrome; CFR ; Centripetal fat ratio; DXA ; Dual-energy x-ray absorptiometry; FM ; Fat mass; FFM ; Fat-free mass; REE ; Resting energy expenditure; MAC ; Midarm circumference; MAMA ; Midarm muscle area; %Fat ; Percent body fat; WHO ; World Health Organization

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K.1999.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objectives: To describe the patterns of growth, nutritional status, body composition, and resting energy expenditure (REE) in prepubertal children with Alagille syndrome (AGS) before the onset of end-stage liver disease. Study design: Thirteen prepubertal subjects with AGS (8 male; mean age, 6.8 ± 2.8 years) were evaluated for growth parameters, body composition by skinfolds and by dual-energy x-ray absorptiometry, and REE by indirect calorimetry. The children with AGS were compared with a healthy, age-matched reference group of 37 prepubertal children. Results: Compared with healthy children, children with AGS had significantly reduced (P < .05) growth (weight, weight z score, height, height z score), nutritional status (midarm circumference, triceps skinfold, and midarm muscle area), and body composition (fat mass and fat-free mass). Subscapular thickness, percent body fat, and REE were not different. The AGS subgroup (n = 4) with REE greater than 110% predicted value had a reduced percent body fat (P < .02). Conclusions: Growth and body composition abnormalities are common in prepubertal children with AGS.

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