Comparison of serum concentrations of a-tocopherol and ß-carotene in a cross-sectional sample of obese and nonobese children (NHANES III)  

Oleh:

Strauss, Richard S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 135 no. 02 (Feb. 1999), page 160-165.
Topik: LDL ; Low-density lipoprotein; NHANES ; National Health and Nutrition Examination Survey

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K.1999.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Introduction: Low intake of the fat-soluble antioxidants a-tocopherol and ß-carotene has been linked to greater risks of cardiovascular disease in epidemiologic studies. Obesity in adults is associated with lower levels of a-tocopherol and ß-carotene, which may contribute to the increased risk of cardiovascular disease associated with obesity. Aim: To examine serum concentrations of fat-soluble antioxidants in a large, nationally representative sample of obese and nonobese children. Methods: Serum levels of a-tocopherol and ß-carotene were measured in 6139 children between the ages of 6 and 19 years enrolled in the National Health and Examination Survey, cycle III. Serum a-tocopherol levels were adjusted for fasting cholesterol and triglyceride levels. Nutritional intake was assessed by 24-hour dietary recall and food frequency questionnaires. Results: Serum levels of ß-carotene were significantly lower in obese children compared with those found in normal weight children (0.22 ± 0.14 µmol/L vs 0.29 ± 0.17 µmol/L, P < .001). After adjustment was done for serum triglyceride and cholesterol levels, a-tocopherol levels were also significantly lower in obese children (2.68 ± 0.59 vs 3.17 ± 0.60, P < .001). Approximately one half of obese children had serum levels of ß-carotene and adjusted a-tocopherol in the lowest quartile compared with approximately one quarter of normal weight children (P < .001). No significant differences were seen in reported intake of ß-carotene, a-tocopherol, fruit, or vegetables between obese and nonobese children. Conclusion: Reduced serum levels of fat-soluble antioxidants are present in obese children.

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