Relationship of progesterone/estradiol ratio on day of hCG administration and pregnancy outcomes in high responders undergoing in vitro fertilization  

Oleh:

Fa-Kung, Lee ; Tsung-Hsuan, Lai ; Tseng-Kai, Lin ; Shang-Gwo, Horng ; Su-Chee, Chen

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 04 (Oct. 2009), page 1284-1289.
Topik: Receptivity; premature luteinization; P/E2 ratio; IVF

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To evaluate the predictive value of a serum P/E2 ratio measured on the day of hCG administration regarding pregnancy outcomes in high responders undergoing IVF. Design Retrospective study. Setting Teaching hospital. Patient(s) Two hundred twenty-three infertile women classified as high responders in IVF-ET cycles. Intervention(s) Eligible infertile women undergoing IVF were assigned to four groups according to serum P levels on the day of hCG administration: group 1, P=0.9 ng/mL; group 2, 0.9 < P=1.4 ng/mL; group 3, 1.4 < P=2.0 ng/mL; group 4, P>2.0 ng/mL. The relationship of E2 level and P/E2 ratio on the day of hCG administration and pregnancy outcomes was analyzed. Main Outcome Measure(s) Implantation and pregnancy rate. Result(s) Patients in group 4 had highest E2 level and P/E2 ratio, as well as lowest implantation and pregnancy rates. Using P for grouping, the sensitivity/positive predictive values (%/%) of P/E2 ratio in the four groups were 15/66, 30/65, 30/60, and 25/41, respectively. Conclusion(s) Using the level of a single sex hormone on hCG day to predict pregnancy outcome in high responders undergoing IVF is confounding, whereas using a P/E2 ratio on hCG day is theoretically reasonable. However, the low sensitivity and positive predictive value make the use of P/E2 clinically unfeasible.

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