Use of Short Echo Time Two-dimensional 1H-Magnetic Resonance Spectroscopy in Temporal Lobe Epilepsy with Negative Magnetic Resonance Imaging Findings  

Oleh:

Shen, J. ; Zhang, L. ; Tian, X. ; Liu, J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 37 no. 04 (Jul. 2009), page 1211-1219.
Topik: Temporal lobe epilepsy; lateralization; magnetic resonance spectroscopy; magnetic resonance imaging; point-resolved spatial selection protocol

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

We evaluated short echo time two-dimensional 1H magnetic resonance spectroscopy (2D-1HMRS) with the point-resolved spatial selection (PRESS) protocol in temporal lobe epilepsy (TLE) patients with negative magnetic resonance imaging (MRI) findings and described the characteristics of 2D-1HMRS in the epileptic focus. Thirty-eight TLE patients with negative conventional MRI findings and 10 healthy controls were studied by 2D-1HMRS. A 128-channel prolonged video-electroencephalographic (EEG) method was used as the standard for epileptogenic focus localization to evaluate N-acetyl aspartate/(choline + creatine + phosphocreatine) (NAA/[Cho + Cr–PCr]), glutamate + glutamine/creatine (Glx/Cr–PCr) and myo-inositol/Cr–PCr ratios in patients with negative MRI findings. The 2D-1HMRS showed that 32/38 patients and all healthy controls had stable baselines and good signal-to-noise ratios. Compared with the healthy controls, 32 patients showed abnormal NAA/(Cho + Cr–PCr) ratios in the hippocampus and, in 25 of these patients, focus lateralization agreed with the EEG. It is concluded that short echo time 2D-1HMRS with the PRESS protocol can help find abnormalities in lateralization of temporal epilepsy in patients with negative MRI findings.

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