Synergistic Effect of a Novel Focal Hyperthermia on the Efficacy of Rifampin in Staphylococcal Experimental Foreign-body Infection  

Oleh:

Zou, G.Y. ; Shen, H. ; Jiang, Y. ; Zhang, X.L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 37 no. 04 (Jul. 2009), page 1115-1126.
Topik: Rifampin; antibiotics; foreign-body infection; methycillin-resistant Staphylococcus aureus; focal hyperthermia

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study was designed to evaluate the efficacy of focal hyperthermia and rifampin in vitro and in vivo using a rabbit model of foreign-body infection by methicillin-resistant Staphylococcus aureus (MRSA). In vitro studies demonstrated bacterial re-growth and development of rifampin resistance after 24 h with rifampin alone, which was prevented under hyperthermic conditions. For the in vivo studies, rifampin was administered intraperitoneally every 12 h for 7 days to rabbits with MRSA-containing cages implanted into their flanks. When combined with hyperthermia at 39 °C, 41 °C and 43 °C, rifampin significantly reduced in-cage bacterial counts by over 3.0 log10 colony forming units/ml compared with rifampin alone. Eradication of cage-associated infection was achieved more effectively when rifampin was combined with hyperthermia, with cure rates of 70 – 95% on day 10. Focal hyperthermia combined with rifampin prevented the emergence of rifampin resistance and maintained rifampin efficacy. These findings might have implications for orthopaedic surgery.

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