A New Target for Tumor Therapy  

Oleh:

Jain, Rakesh K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 360 no. 25 (Jun. 2009), page 2669-2671 .
Topik: prolyl hydroxylase domain 2 (PHD2) protein; tumor

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Vascular normalization, or restoration of the normal structure and function in blood vessels, has emerged as a strategy to treat cancer and other vascular disorders. Mazzone et al. have recently proposed a new approach for vascular normalization — targeting the prolyl hydroxylase domain 2 (PHD2) protein, an oxygen sensor that tags hypoxia-induced transcription factors for degradation. These authors found that haplodeficiency (i.e., half the "normal" dose) of PHD2 in endothelial cells "normalizes" abnormal endothelial cells in tumors, resulting in increased tumor oxygenation and decreased metastasis.

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