Detail A Study of Some Biochemical Parameters of Pulmonary Hypertension in Children with Congenital and Rheumatic Heart Disease (Alexandria Journal of Pediatrics, Vol. 19, No. 1, January 2005) Bibliografi Author: El-Deeb, Safiea A. ; Amry, Salah-Eldin ; El-Metwally, Tarek H. ; Al-Jefri, Hasan M. A. Topik: Pulmonary Hypertension; Congenital Heart Diseas; Rheumatic Heart Disease Bahasa: (EN )    Edisi: January 2005     Tahun Terbit: 2005     Jenis: Journal - ilmiah internasional Fulltext: A Study of Some Biochemical Parameters of Pulmonary.pdf (82.09KB; 6 download) Abstract The study included 36 cases with congenital heart disease (CHD) all of them had left to right shunt (17 cases of them had pulmonary hypertension [PHT]), 30 cases with valvular rheumatic heart disease (RHD) (15 of whom had PHT). Ten healthy normal age-matched children were taken as control for each group. Full history and physical examination, pulse oximetry, standard 13-lead ECG and detailed echocardiographic examination were done for every patient and control case. Chest radiograph posteranterior view in erect position was done for all patients. Erythrocytic sedimentation rate, C-reactive protein and antistreptolysin-O titer were done for patients with RHD. All cases and controls had the following done: plasma level of endothelin-1 (ET-1), angiotesin-II (ANG-II), nitric oxide (NO) and serum level of angiotesin –converting enzyme (ACE) activity. The mean peak pulmonary pressure (PP) in patients having CHD and PHT was 54.36 + 9.69 mm Hg, while it was 61.73 + 11.55 mm Hg in those with RHD and PHT. The mean peak PP in the group of patients having CHD without PHT was 22.64 + 4.11 mm Hg. It was significantly higher than in those with RHD without PHT (9.41 + 1.98 mm Hg, P<0.05) and than controls (4.12 + 1.25, P<0.01). It was observed that the mean levels of ET-1, NO, ANG-II and ACE were significantly higher in all cases with CHD (3.42 + 0.77, 77.21 + 29.14, 81.27 + 37.3, 107.2 + 47.65, P<0.001), cases with PHT (3.76 + 0.81, 94.1 + 21.1, 101.4 + 33.8, 136.2 + 37.9, P<0.001) or without PHT (2.92 + 0.6, 61.36 + 27.5, 63.28 + 16.5, 85.36 + 22.6, P<0.5 &0.01) than in their controls (1.86 + 0.6, 34.07 + 10.7, 19.15 + 10.9, 54.1 + 32.1). It was observed that the mean level of ET-1, NO, ANG-II and ACE were significantly higher in cases with CHD with PHT than in those without PHT (P<0.05 for each). In the group of patients with RHD, it was observed that the mean levels of ET-1, NO, ANG-II and ACE were significantly higher in all cases [3.89 + 1.4, 78.46 + 59, 70.35 + 37.4, P<0.01 & 0.001] and cases with PHT [4.9 + 1.0, 100.5 + 32, 95.7 + 36.8, 121 + 40.9, P<0.001] than in controls [1.55 + 0.5, 33.47 + 13.0, 22.68 + 11.1, 53.27 + 32.4]. It was also observed that the mean levels of ET-1, NO, ANG-II and ACE were significantly higher in cases with than in those without PHT [2.6 + 0.8, 56.5 + 18.0, 44.96 + 12.7, 63.3 + 37] (P<0.01). It was observed that the mean levels of ET-1, ANG-II and ACE were significantly higher in cases with CHD having heart failure (3.8 + 0.73, 106.8 + 50.37, 155.3 + 65.66) than those without heart failure (3.26 + 0.7, 69.88 + 25.1, 91.85 + 32.8), P<0.05,0.05 & 0.001. There was statistically significant positive correlation between PP in all the studied patients and serum level of ET-1, NO, ANG-II, and ACE (P< 0.001). A significant positive correlation was found between serum level of ET-1 and NO in all the studied cases (P< 0.05). A significant positive correlation was also found between serum level of ANG-II and ACE in all the studied cases (P< 0.03). Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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