Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome  

Oleh:

Kotsa, Kalliopi ; Yavropoulou, Maria P. ; Anastasiou, Olympia ; Yovos, John G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 03 (Sep. 2009), page 1053-1058.
Topik: Vitamin D3 treatment; PCOS insulin sensitivity; insulin resistance; lipid profile

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To determine the effect of treatment with vitamin D3 analogue in the parameters of glucose metabolism in obese women with polycystic ovary syndrome (PCOS). Design Observational study. Setting Obese women with PCOS in an academic research environment. Patient(s) Fifteen obese women (mean age 28 ± 1.3 years, mean body mass index 32.55 ± 0.43) with documented chronic anovulation and hyperandrogenism were recruited into the study. Intervention(s) Alphacalcidol (1-a-hydroxyvitamin D3) was administered orally 1 µg/day for 3 months. All subjects underwent a frequently sampled IV glucose tolerance test after a 10- to 12-hour overnight fast during a spontaneous bleeding episode before and after treatment with alphacalcidol. Main Outcome Measure(s) Peripheral insulin resistance and insulin effectiveness were estimated with minimal model. Result(s) The first phase of insulin secretion was significantly increased after treatment with alphacalcidol. A favorable statistically significant change also was observed in the lipid profile. Conclusion(s) Treatment with the vitamin D3 analogue (alphacalcidol) could be of value in the management of PCOS.

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