Comparison of low-dose human menopausal gonadotropin and micronized 17ß-estradiol supplementation in in vitro maturation cycles with thin endometrial lining  

Oleh:

Elizur, Shai E. ; Weon-Young, Son ; Yap, Raymond ; Gidoni, Yariv ; Levin, Dan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 03 (Sep. 2009), page 907-912 .
Topik: In vitro maturation (IVM); endometrium; human menopausal gonadotropins (hMG); estrogen

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective A challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer. Design Retrospective study. Setting McGill Reproductive Center, Montreal, Canada. Patient(s) Women with endometrial thickness <6 mm on days 6–10 ultrasound (US) scan of IVM treatment. Intervention(s) In the human menopausal gonadotropin (hMG) group, 150 IU/day of hMG was started and in the estradiol group, 6 to 12 mg/day of micronized 17ß-estradiol was initiated. Additional US scans were performed 2 to 3 days apart, until endometrial thickness reached =8 mm or a dominant follicle (>10 mm) was identified. Main Outcome Measure(s) Endometrial lining before oocyte retrival. Result(s) In both groups endometrial lining significantly thickened following treatment. However, hMG treatment resulted in a higher number of follicles =7 mm compared to estradiol (7.4 ± 4.8 vs. 3.4 ± 2.5, respectively) and a significantly higher percentage of mature oocytes that were identified on the day of oocyte retrieval (in vivo matured oocytes) (15.1% vs. 10.5%). Conclusion(s) In IVM designated cycles with a thin endometrium both low-dose hMG and micronized 17ß-estradiol supplementation significantly improve endometrial thickness. However, low-dose hMG results in larger follicles and a greater number of in vivo matured oocytes.

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