Prospect of Nucleic - Acid Based Immune System - RNAi as Potent Antiviral Agents  

Oleh:

Soejitno, Andreas ; Permadi, Prichilia Sarah ; Wihandani, Desak Made

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Cermin Dunia Kedokteran vol. 36 no. 05/171 (Aug. 2009), page 340-343.
Topik: nucleic-acid based; immune system; RNAi; antiviral

Ketersediaan

Perpustakaan FK Nomor Panggil: C04.K.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

RNAi, also known as RNA silencing or post-transcriptional gene silencing is a mechanism of inactivating specific target gene expressions by reducing their rates of transcription, stability of target mRNAs, or the translational process of those mRNAs, thereby promoting degradation of the related RNAs. Critical event leading up to the discovery of RNAi in mammals is investigated by Guo and Kemphues who successfully inhibit gene expression of nematode C.elegans using sense or antisense single strand RNA (ssRNA). Later,Fire et.al discovered that double-stranded RNA (dsRNA) is more potent than sense or antisense ssRNA in silencing gene expression of the same species; this mechanism was named RNA interference.

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