The Deceiving Appearances of Osteoclasts  

Oleh:

Glowacki, Julie

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 360 no. 01 (Jan. 2009), page 80-82.
Topik: Osteoclasts; bone matrix; growth of a human

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Osteoclasts are multinucleated cells responsible for the resorption of bone matrix. During the development and growth of a human, they ensure proper contouring of the bones and extension of the medullary spaces to provide for hematopoiesis. In the adult skeleton, osteoclasts ensure remodeling of the bone matrix by means of a process of internal turnover. Skeletal homeostasis is achieved by focal osteoclast-mediated degradation of the bone matrix and osteoblast-mediated formation of new bone matrix without compromising the overall architecture and anatomy of bones. Under ideal conditions, the amount of new bone equals the amount resorbed, with no net change in the volume of bone. As a consequence of remodeling, the molecular composition of the adult skeleton is not static but changes as new bone fills each resorption site. Thus, new carbonato–calcium phosphate crystals replace the highly crystalline, less soluble mature mineral component of bone.1 The renewal of bone matrix is central for the important role bone has in mineral exchange and homeostasis.

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