Allopurinol and Nitric Oxide Activity in the Cerebral Circulation of Those With Diabetes  

Oleh:

Dawson, Jesse ; Quinn, Terry ; Harrow, Craig ; Lees, Kennedy R. ; Weir, Christopher J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 32 no. 01 (Jan. 2009), page 135-137 .
Topik: cerebrovascular

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE—Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity. We investigated whether this activity is improved by a 2-week course of the xanthine oxidase inhibitor allopurinol. RESEARCH DESIGN AND METHODS—We performed a randomized, double-blind, placebo-controlled crossover study. We measured the response to infusion of NG-monomethyl-L-arginine (l-NMMA) in males with type 2 diabetes before and after allopurinol or placebo. The primary end point was the change in internal carotid artery flow following l-NMMA infusion, expressed as the area under the flow-per-time curve. RESULTS—We enrolled 14 participants. Allopurinol improved responses to l-NMMA when compared with responses associated with placebo (P = 0.032; median reduction in internal carotid artery flow following l-NMMA of 3,144 ml [95% CI 375–7,143]). CONCLUSIONS—Xanthine oxidase inhibition with allopurinol appears to improve cerebral NO bioavailability, as evidenced by a greater response to infusion of l-NMMA.

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