Genetic Trickery — Escape of Leukemia from Immune Attack  

Oleh:

Barrett, John ; Blazar, Bruce R.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 05 (Jul. 2009), page 524-525 .
Topik: Leukemia

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

It is increasingly clear that neoplastic cells and the immune system are locked in a struggle in which each attempts to outmaneuver its opponent. One tactic that tumors use to avoid attack by T cells and natural killer cells is the suppression of immune-recognition molecules.1 Evasion by this means is possible when cancer cells lose an HLA haplotype that was inherited from one of the patient's parents and replace it with a haplotype from the other parent. The loss occurs during mitotic recombination, leaving the daughter cell with two HLA haplotypes derived from only one parent — hence the term "uniparental disomy."2 The chromosome number remains unchanged, and for this reason standard cytogenetic techniques fail to detect the swap.

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