Changes in Basal Insulin Infusion Rates With Subcutaneous Insulin Infusion : Time until a change in metabolic effect is induced in patients with type 1 diabetes  

Oleh:

Heinemann, Lutz ; Nosek, Leszek ; Kapitza, Christoph ; Schweitzer, Matthias-Axel ; Krinelke, Lars

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 32 no. 08 (Aug. 2009), page 1437-1439 .
Topik: Subcutaneous Insulin

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE : Evaluation of the time required until a change in the basal insulin infusion rate with an insulin pump induces subsequent changes in the metabolic effect. RESEARCH DESIGN AND METHODS : In this euglycemic glucose clamp study, 10 male subjects with type 1 diabetes received three different subcutaneous insulin infusion rates (0.5, 1.0, and 2.0 units/h; for 4 h each) of insulin lispro (IL) with insulin pumps. RESULTS : An increase in insulinemia occurred within 15–30 min after changing the infusion rate. While the serum IL levels reached a steady state at the end of the infusion period, the glucose infusion rates did not always reach steady-state levels with the higher infusion rates. However, an increase in the glucose consumption occurred within 30–60 min after switching the infusion rate. CONCLUSIONS : Several hours are required until a new steady state in the metabolic effect is achieved after a significant change in basal insulin infusion.

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