Valdecoxib Provides Effective Pain Relief Following Acute Ankle Sprain  

Oleh:

Diaz, J.A. ; Cuervo, C. ; Valderrama, A.M. ; Kohles, J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 34 no. 05 (Sep. 2006), page 456-467.
Topik: Valdecoxib; diclofenac; cyclooxygenase (COX)-2 inhibitors; ankle sprain; pain

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.05-06.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

We sought to determine whether valdecoxib is as effective as diclofenac in treating acute ankle sprain. Patients (n = 202) with acute first- and second-degree ankle sprain were randomized to valdecoxib (40 mg twice daily on day 1 followed by 40 mg once daily on days 2 – 7) or diclofenac (75 mg twice daily). The primary efficacy end-point was the Patient’s Assessment of Ankle Pain visual analogue scale (VAS, 0 – 100 mm) value on day 4. Valdecoxib was as efficacious as diclofenac in treating the signs and symptoms of acute ankle sprain. The mean VAS reduction in ankle pain on day 4 was not different between groups; the two-sided 95% confidence interval for the between-group difference was within the pre-specified limit for non-inferiority (10 mm). There were no significant differences between groups for all secondary efficacy end-points. The two treatments were similarly effective and well tolerated for treatment of acute ankle sprain.

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