Detail A Nitric Oxide–Inducible Lactate Dehydrogenase Enables Staphylococcus aureus to Resist Innate Immunity   Oleh:  Richardson, Anthony R. ; Libby, Stephen J. ; Fang, Ferric C. Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 319 no. 5870 (Mar. 2008), page 1672-1675. Topik: A Nitric Oxide–Inducible Lactate Dehydrogenase; Staphylococcus aureus; Innate Immunity Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2008.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Staphylococcus aureus is one of the most successful human pathogens, colonizing 2 billion individuals worldwide and causing invasive infections even in immunocompetent hosts. S. aureus can evade multiple components of host innate immunity, including the antimicrobial radical nitric oxide (NObullet) produced by activated phagocytes. We show that S. aureus is capable of metabolically adapting to nitrosative stress by expressing an NObullet-inducible L-lactate dehydrogenase (ldh1, SACOL0222) divergently transcribed from the NObullet-detoxifying flavohemoglobin (hmp). L-Lactate production allows S. aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence. NObullet-inducible lactate dehydrogenase activity and NObullet resistance distinguish S. aureus from the closely related commensal species S. epidermidis and S. saprophyticus. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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