Detail Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development   Oleh:  Setoguchi, Ruka ; Tachibana, Masashi ; Naoe, Yoshinori ; Muroi, Sawako Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 319 no. 5864 (Feb. 2008), page 822-824. Topik: Repression; Transcription Factor Th-POK; Runx Complexes; Cytotoxic T Cell Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Mouse CD4+CD8+ double-positive (DP) thymocytes differentiate into CD4+ helper-lineage cells upon expression of the transcription factor Th-POK but commit to the CD8+ cytotoxic lineage in its absence. We report the redirected differentiation of class I–restricted thymocytes into CD4+CD8– helper-like T cells upon loss of Runx transcription factor complexes. A Runx-binding sequence within the Th-POK locus acts as a transcriptional silencer that is essential for Th-POK repression and for development of CD8+ T cells. Thus, Th-POK expression and genetic programming for T helper cell development are actively inhibited by Runx-dependent silencer activity, allowing for cytotoxic T cell differentiation. Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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