Amyloid b Protein Deposition in Osteopetrotic (op/op) Mice Is Reduced by Injections of Macrophage Colony Stimulating Factor  

Oleh:

Kawata, T. ; Tsutsui, K. ; Kohno, S. ; Kaku, M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 33 no. 06 (Nov. 2005), page 654-660.
Topik: Macrphage colony stimulating factor (M-CSF); colony stimulating factor 1 (CSF-1); Alzheimer's disease; op/op mouse; amyloid beta protein

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.05-06.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The deposition of amyloid b (Ab) protein is a neuropathological change that characterizes Alzheimer’s disease. Animals with the osteopetrosis (op/op) mutation suffer from a general skeletal sclerosis, a significantly reduced number of macrophages and osteoclasts in various tissues, and have no systemic macrophage colony stimulating factor (M-CSF). This study examined the effect that M-CSF injections had on Ab deposition and microglial cell distribution in the brains of normal and op/op mice. Ab-positive plaques were detected in the cerebral cortex of op/op mice, but not in normal mice. M-CSF reduced the numbers of Ab-positive plaques in op/op mice. The microglial cell population was reduced in op/op mice compared with normal mice, and M-CSF increased the numbers to 65.8% of that observed in normal mice. Our results suggest that a clearer understanding of the role that microglial cells play in Ab deposition may help determine the mechanisms involved in the pathogenesis of Alzheimer’s disease.

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