Comparison of Tuberculin Skin Test and a Specific T-cell-based Test, T-Spot™.TB, for the Diagnosis of Latent Tuberculosis Infection  

Oleh:

Ozekinci, T. ; Ozbek, E. ; Celik, Y.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 35 no. 05 (Sep. 2007), page 696-703.
Topik: Tuberculin skin test; specific T-cell-based test; T-Spot™.TB; latent tuberculosis infection

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

There is substantial evidence that the detection of T cells specific for the proteins ESAT-6 and CFP-10 using the ex vivo enzyme-linked immunospot technique is a marked improvement on the existing tuberculin skin test (TST). This new technique, which detects gamma-interferon-producing T cells, is now available as the commercial assay, T-Spot™.TB. We compared the T-Spot™.TB test with the TST for the diagnosis of latent tuberculosis infection (LTBI) in different groups of subjects. Significant accordance (85.7%) between the tests was found in subjects with active lung tuberculosis and in tuberculosis clinic and laboratory personnel (63.6%) but accordance was lowest and not significant amongst house contacts of tuberculosis patients (53.6%). We conclude that, in countries where vaccination is routinely performed, the T-Spot™.TB test is a useful diagnostic test for LTBI in high-risk groups when carried out either together with the TST and/or to confirm the TST result.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali