Is the Application of Prostaglandin E1 Effective for the Treatment of Sudden Hearing Loss? An Evidence-based Meta-analysis  

Oleh:

Xian-Lu, Zhuo ; Yan, Wang ; Wen-Lei, Zhuo ; Xue-Yuan, Zhang

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 36 no. 03 (May 2008), page 467-470.
Topik: Prostaglandin E1

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2008.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Microvascular dysfunction in the cochlea has been considered the major cause of sudden hearing loss (SHL). For some time, prostaglandin E1 (PGE1), an effective vasodilator, has been used to treat patients with SHL, however the benefits of this therapy remain unclear. The present study assessed the efficacy of PGE1 on SHL via a quantitative meta-analysis of 13 randomized controlled studies. The pooled odds ratio was 1.95 (95% confidence interval: 1.53, 2.50) and the test for overall effect (Z-value) was 5.31 (P < 0.00001), suggesting that PGE1 is an effective and promising strategy for the treatment of SHL.

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