Effect of Lipo-PGE1 on Health-related Quality of Life in Patients with Systemic Sclerosis and Systemic Lupus Erythematosus in Japan  

Oleh:

Hoshi, K. ; Fukuhara, S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 36 no. 01 (Jan. 2008), page 187-197.
Topik: Lipo-PGE1; Systemic Sclerosis; Systemic Lupus Erythematosus

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2008.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

We investigated the effect of Lipo-PGE1, a prostaglandin (PG) E1 preparation used to treat cutaneous ulcers associated with systemic sclerosis (SS) and systemic lupus erythematosus (SLE), on health-related quality of life (HR-QOL) using the Medical Outcome Study 36-item Short-Form Health Survey (SF-36) questionnaire. A total of 192 SS and SLE patients were treated for 3 months. At baseline the scores for each of the five SF-36 subscales were significantly lower than the age- and sex-adjusted standard values for the Japanese general population. After treatment, mean (+/– SD) SF-36 scores for body pain and general health perception significantly increased from 48.6 +/– 24.1 to 55.3 +/– 26.1 and from 36.8 +/– 16.7 to 40.2 +/– 17, respectively. Emotional QOL parameters including vitality and mental health, however, showed no improvement. Physician-rated symptom scores significantly improved after administration of Lipo-PGE1. In conclusion, Lipo-PGE1 improved both cutaneous ulcers and HRQOL, especially physical QOL.

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