Evaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitis  

Oleh:

Yilmaz, C. ; Yuca, S.A. ; Yilmaz, N. ; Oner, A.F.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 37 no. 03 (May 2009), page 828-834.
Topik: Lymphocyte; Sclerosing Panencephalitis

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The aetiology of subacute sclerosing panencephalitis (SSPE) remains to be fully elucidated, although it follows infection with a hypermutant defective M-protein measles virus. This study analysed peripheral blood lymphocyte subgroups to determine their role in the pathophysiology of SSPE. It included 22 children with SSPE aged 2 – 15 years (patient group) and 22 age- and gender-matched healthy children (control group). In children under 6 years old, there were no statistically significant differences between the two groups in the proportions of lymphocytes expressing the surface markers CD3, CD8, CD19 or CD16/56, or in CD4/CD8 ratio. The proportion of CD4+ lymphocytes in SSPE patients under 6 years of age was significantly lower compared with the control group. In children 6 years old or over, there were no significant differences in the lymphocyte subgroups. In conclusion, these findings suggest that a low CD4+ lymphocyte count might be responsible for SSPE in younger children.

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