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Gene Regulation by Transcription Factors and MicroRNAs
Oleh:
Hobert, Oliver
Jenis:
Article from Bulletin/Magazine
Dalam koleksi:
SCIENCE (keterangan: ada di Proquest) vol. 319 no. 5871 (Mar. 2008)
,
page 1785-1786.
Ketersediaan
Perpustakaan FK
Nomor Panggil:
S01.K.2008.03
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor– and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression.
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