Tumor necrosis factor a and lymphotoxin a haplotypes in idiopathic recurrent pregnancy loss  

Oleh:

Zammiti, Walid ; Mtiraoui, Nabil ; Finan, Ramzi R. ; Almawi, Wassim Y. ; Mahjoub, Touhami

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 05 (May 2009), page 1903-1908.
Topik: Tumor necrosis factor; lymphotoxin; recurrent miscarriage

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To investigate the contribution of the -238G/A and -308G/A tumor necrosis factor (TNF) a, and +252A/G lymphotoxin (LT) a gene polymorphisms to idiopathic recurrent miscarriage (RM). Design : A retrospective case-control study. Setting : Outpatient maternity center. Patient(s) : Study subjects comprised 372 RM women and 274 age-matched parous control women. Intervention(s) : None. Main Outcome Measure(s) : The TNFa and LTa gene variants and idiopathic RM. Result(s) : Higher prevalence of TNFa -238A and LTa +252G alleles and LTa +252G/G genotype and lower frequencies of TNFa -308G/A were seen in RM cases. Three-loci haplotype analysis (TNFa -308GA/TNFa -238GA/LTa +252AG) demonstrated significant association between TNFa-LTa gene variants and RM. Both protective [-308A/-238G/+252A], and susceptible [-308G/-238A/+252G] haplotypes were identified. Mutlivariate regression analysis confirmed the association of -308G/-238A/+252G haplotype with exclusively early RM, after controlling for a number of covariates; no specific TNFa and LTa genotypes or haplotypes were linked with either late or combined early and late RM. Conclusion(s) : The TNFa -238G/A and LTa +252A/G, but not TNFa -308G/A, polymorphic variants are associated with exclusively early idiopathic RM.

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