Follicular and endocrine response to anastrozole versus clomiphene citrate administered in follicular phase to normoovulatory women: a randomized comparison  

Oleh:

Griesinger, Georg ; Otte, Soren von ; Schultze-Mosgau, Askan ; Diedrich, Klaus ; Schroer, Andreas

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 05 (May 2009), page 1831-1836.
Topik: Anastrozole; clomiphene citrate; aromatase inhibitor; ovulation induction; ovarian stimulation; arimidex; femara

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To compare the effect on follicular growth and endocrine parameters of follicular phase administration of anastrozole to healthy, normoovulatory women in doses of 1 or 5 mg, respectively, with the conventional dosing regimen for ovulation induction with clomiphene citrate (CC). Design : Randomized, assessor-blinded, single-center, three-armed study. Setting : University-affiliated, tertiary referral center. Patient(s) : Thirty-two, normoovulatory, normogonadotropic women. Intervention(s) : Administration of anastrozole 1 mg (group A1), anastrozole 5 mg (group A5), or CC 50 mg (group CC50) from cycle days 3 to 7. Main Outcome Measure(s) : Number of follicles =15 mm and =10 mm on the day of the endogenous LH surge. Result(s) : The mean number of follicles =15 mm on the day of LH surge was 1.4 ± 0.5, 1.0 ± 0.4, and 0.8 ± 0.4 in groups CC50, A1, and A5, respectively, which was statistically significant. Furthermore, a statistically significant difference between groups was found for the size of the growing follicular cohort (follicles =10 mm) on cycle days 8 and 10 and on the day of LH surge. The area under the curve (adjusted for baseline values on cycle day 3 and time frame of assessment) of follicular phase E2 levels was significantly different among the groups that were compared (223.0 ± 97.5, 69.2 ± 40.0, and 83.4 ± 36.4 for groups CC50, A1, and A5, respectively). Conclusion(s) : CC 50 mg exerts a stronger stimulatory effect on follicular growth compared with anastrozole in doses of 1 or 5 mg. Anastrozole administration results in lower follicular phase E2 levels.

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