Logarithmic curves depicting initial level and rise of serum beta human chorionic gonadotropin and live delivery outcomes with in vitro fertilization: An analysis of 6021 pregnancies  

Oleh:

Shamonki, Mousa I. ; Frattarelli, John L. ; Bergh, Paul A. ; Scott, Richard T.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 05 (May 2009), page 1760-1764.
Topik: Human chorionic gonadotropin; pregnancy rate; implantation rate; live delivery rate; multiple gestation; in vitro fertilization; frozen embryo; blastocyst

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To correlate the live delivery rate with the initial level and rise of serum ß-hCG. Design : Retrospective cohort analysis. Setting : Large private academic center for assisted reproductive technologies and infertility. Patient(s) : Records of all patients from 1999 to 2005 undergoing IVF with detectable early serum ß-hCG after ET. Intervention(s) : None. Main Outcome Measure(s) : Live delivery rate. Result(s) : Data from 6021 pregnancies were analyzed. Initial ß-hCG was predictive for delivery rate for all patients and for each age group. After controlling for the first ß-hCG, there were higher loss rates as age increased. Percent rise in second ß-hCG drawn 2 days later added predictive value. A decline in ß-hCG almost always resulted in a failure to deliver. There was a progressive increase in delivery rate as the percent rise in ß-hCG went from 0 to 100%; however, there was no further enhancement in delivery rates beyond the 100% rise point. While a better rise in ß-hCG was a good prognostic factor in all age groups, the differences in outcomes for the different age groups remained, even after controlling for first ß-hCG and percent rise. Conclusion(s) : Initial level and rise in ß-hCG predicts live delivery rate, with oocyte age providing additional predictive value. The established logarithmic curves should provide convenient reference tools for tracking outcomes and counseling patients.

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