Premature luteinization and in vitro fertilization outcome in gonadotropin/gonadotropin-releasing hormone antagonist cycles in women with polycystic ovary syndrome  

Oleh:

Segal, Shimon ; Glatstein, Isaac ; McShane, Patricia ; Hotamisligil, Selen

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 05 (May 2009), page 1755-1759.
Topik: PCOS; in vitro fertilization; GnRH-antagonist; premature luteinization; controlled ovarian hyperstimulation

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To determine the incidence of premature luteinization in patients with polycystic ovary syndrome (PCOS) undergoing controlled ovarian hyperstimulation (COH) with exogenous gonadotropin/GnRH antagonist (GnRH-a); to compare clinical outcomes in patients with and without premature luteinization. Design : Retrospective case series. Setting : IVF clinic. Patient(s) : Thirty-five treatment cycles in 30 patients with PCOS. Intervention(s) : Controlled ovarian hyperstimulation with gonadotropin/GnRH-a protocol. Main Outcome Measure(s) : Premature luteinization defined as a P concentration of =1.3 ng/mL on the day of hCG administration; number of oocytes and two pronuclei (2PN) embryos; implantation and clinical pregnancy rates (PR). Result(s) : The incidence of premature luteinization was 28%. Compared with those without premature luteinization, patients with premature luteinization had a higher number of oocytes retrieved (24.1 ± 13.3 vs. 12.0 ± 5.9) and greater number of mature oocytes (19.7 ± 11.7 vs. 9.5 ± 4.5), respectively. The number of good quality embryos and embryos transferred was not significantly different between groups. Although implantation rates (56% vs. 40%) and clinical PRs (36% vs. 30%) were higher in patients without premature luteinization, the differences were not statistically significant. Conclusion(s) : The patients with PCOS with premature luteinization had a higher number of oocytes retrieved and mature oocytes, and similar clinical PRs as patients with PCOS without premature luteinization.

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