Follicular fluid and serum levels of Inhibin A and pregnancy-associated plasma protein A in patients undergoing IVF  

Oleh:

Moos, Jiri ; Filova, Vanda ; Pavelkova, Jana ; Moosova, Martina

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 05 (May 2009), page 1739-1744.
Topik: Follicular fluid/blood barrier; protein transport; PAPP-A; Inhibin A; IVF

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To elucidate transport of intrafollicular proteins Inhibin A and pregnancy-associated plasma protein A (PAPP-A) across the follicular fluid (FF)/blood barrier. Design : A retrospective study. Setting : IVF lab at a university hospital, academic, and industrial research labs. Patient(s) : Fifty-five women undertook the IVF program. Intervention(s) : Follicular fluid aspirations and analysis, blood sample drawing, and serum analysis. Main Outcome Measure(s) : Concentrations of Inhibin A, PAPP-A, and major serum proteins in FF and serum, total amount of PAPP-A, and Inhibin A in FF. Result(s) : The FF/blood barrier permeability was calibrated using major serum proteins. The FF/serum ratio decreased with the molecular mass of proteins, and their FF and serum concentrations were well correlated. In contrast, concentrations of Inhibin A in paired serum and FF samples showed a weak correlation (r = 0.563), whereas serum and FF concentrations of PAPP-A were independent of each other. The total amount of Inhibin A in FF correlated well with concentrations of Inhibin A in paired serum samples (r = 0.858), whereas the correlation between the total amount of FF PAPP-A and PAPP-A serum concentrations remains poor (r = 0.215). Conclusion(s) : These observations suggest that at the day of oocyte retrieval, FF is a major source of serum Inhibin A but not of serum PAPP-A.

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