Impact of day 3 or day 5 embryo transfer on pregnancy rates and multiple gestations  

Oleh:

Beesley, Ronald ; Robinson, Randal ; Propst, Anthony ; Arthur, Nancy ; Retzloff, Matthew

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 05 (May 2009), page 1717-1720.
Topik: Embryo transfer; blastocyst transfer; multiple gestation

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To test the hypothesis that day 5 ET (D5ET) is superior to day 3 ET (D3ET) in pregnancy outcome and that it also reduces multiple gestations. Design : Retrospective cohort study. Setting : Assisted reproductive technologies program at Wilford Hall Medical Center. Patient(s) : Patients electing for either D3ET or D5ET. Intervention(s) : Participants meeting inclusion criteria for D5ET elected either D3ET or D5ET. Main Outcome Measure(s) : Cycles were compared by day of transfer and further stratified by patient age (<35 years and 35–40 years). The number of oocytes retrieved, embryos on day 3, embryos transferred, pregnancy rate, implantation rate, and twin and high order multiples (=triplets) rates were compared. Result(s) : Of the 274 patients who met our inclusion criteria, 153 underwent a D3ET and 121 underwent a D5ET. The D5ET group had a significantly lower mean age and number of embryos transferred and a higher implantation rate (56% vs. 42%) than the D3ET group. Patients who were 35–40 years old had a significantly higher live-birth rate (68% vs. 40%). Although not statistically significant, the D5ET groups had higher clinical pregnancy (73% vs. 65%) and twin pregnancy (33% vs. 25%) rates. Conclusion(s) : Blastocyst transfer resulted in fewer embryos transferred, with a trend toward improved clinical pregnancy and higher twin pregnancy rates. Live-birth rates were improved in patients 35–40 years of age. Younger patients opting for D5ET should do so with a commitment toward single ET.

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