The value of vascular endothelial growth factor, pregnancy-associated plasma protein-A, and progesterone for early differentiation of ectopic pregnancies, normal intrauterine pregnancies, and spontaneous miscarriages  

Oleh:

Ugurlu, Evin Nil ; Ozaksit, Gulnur ; Karaer, Abdullah ; Zulfikaroglu, Ebru

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 05 (Mei 2009), halaman 1657-1661.
Topik: Ectopic pregnancy; PAPP-A; sensitivity; specifity; VEGF

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To evaluate the capacity of vascular endothelial growth factor (VEGF), pregnancy-associated plasma protein-A (PAPP-A), and progesterone (P) to discriminate ectopic pregnancies (EP) from nonectopic ones. Design : Prospective, case-controlled study. Setting : Tertiary care center. Patient(s) : Twenty-nine women with EP, 29 women with normal intrauterine pregnancy (nIUP), and 28 women with spontaneous miscarriage, all matched for gestational age. Intervention(s) : Serum samples were obtained. Main Outcome Measure(s) : Serum concentrations of VEGF, PAPP-A, and P were measured. Result(s) : Serum VEGF concentrations did not show statistically significant differences among women with EP (median, 55.24 pg/mL; range, 0.20–179.24), spontaneous miscarriages (median, 26.24 pg/mL; range, 0.22–365.24), and nIUP (median, 43.24 pg/mL; range, 0.86–101.24). The median level of P was significantly increased in the nIUP group (20.58 ng/mL; range, 13.9–37.04) compared with the other two groups, but there was no statistically significant difference between the spontaneous miscarriage and EP groups. Like P, PAPP-A values were also significantly higher in the nIUP group than in the other two groups, but the difference between PAPP-A values in the EP and spontaneous abortion groups was statistically insignificant. Conclusion(s) : VEGF, PAPP-A, and P cannot be used to diagnose EPs, but PAPP-A and P can at least be used to differentiate abnormal pregnancies.

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