Return to fertility after cessation of a continuous oral contraceptive  

Oleh:

Barnhart, Kurt T. ; Mirkin, Sebastian ; Grubb, Gary ; Constantine, Ginger

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 05 (May 2009), page 1654-1656.
Topik: Return to fertility; oral contraceptive; low-dose; continuous; noncyclic

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To evaluate the return to fertility among women planning to become pregnant after the use of a continuous regimen of levonorgestrel 90 µg and ethinyl E2 20 µg. Design : Descriptive analysis of pregnancy outcomes after participation in a contraceptive trial. Setting : Multicenter trial. Subject(s) : Participants in a phase 3 contraceptive trial who discontinued to become pregnant. Intervention(s) : Eligible subjects were contacted at 3 and 12 months after treatment discontinuation to determine if and when they had conceived. Main Outcome Measure(s) : Kaplan-Meier analysis displaying the time until conception after oral contraceptive discontinuation. Result(s) : In the phase 3 trial, 34 of 2,134 subjects cited a desire for pregnancy as a reason for discontinuation. Of these, 4 were already pregnant before stopping treatment, 4 initiated other contraception, and 5 were lost to follow-up. Of the remaining 21 subjects at risk of pregnancy, the pregnancy rate was 57% at 3 months, 81% at 12 months, and 86% (18 of 21) (95% confidence interval 64% to 97%) at 13 months after discontinuation of treatment. Conclusion(s) : These findings suggest that a continuous oral contraceptive with levonorgestrel 90 µg and ethinyl E2 20 µg does not delay the return to fertility.

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