Dietary Soy Protein Isolate Attenuates Metabolic Syndrome in Rats via Effects on PPAR, LXR, and SREBP Signaling1–3,  

Oleh:

Ronis, Martin J. ; Ying, Chen ; Badeaux, Jamie ; Badger, Thomas M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 139 no. 08 (Aug. 2009), page 1431-1438.
Topik: the effects of feeding soy or isoflavones; lipid homeostasis; AIN-93G ; soy protein isolate (SPI+); isoflavone-reduced SPI+ (SPI–); or casein supplemented with genistein or daidzein for 14 d. PPAR-regulated genes; promoter binding of LXR; d (PND) 24 to PND64

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

To determine the effects of feeding soy or isoflavones on lipid homeostasis in early development, weanling rats were fed AIN-93G diets made with casein, soy protein isolate (SPI+), isoflavone-reduced SPI+ (SPI–), or casein supplemented with genistein or daidzein for 14 d. PPAR-regulated genes and proteins involved in fatty acid degradation were upregulated by SPI+ (P < 0.05) accompanied by increased promoter binding and expression of PPAR mRNA (P < 0.05). Feeding SPI– or pure isoflavones did not alter PPAR-regulated pathways. SPI+ feeding had similar effects on PPAR signaling. SPI+, SPI–, and casein plus isoflavones all increased liver X-receptor (LXR)-regulated genes and enzymes involved in cholesterol homeostasis. Feeding SPI+ increased promoter binding of LXR, expression of the transcription factor mRNA, and protein (P < 0.05). In a second experiment, male Sprague-Dawley rats were fed casein diets from postnatal d (PND) 24 to PND64 or were fed high-fat Western diets containing 5 g·kg–1 cholesterol made with either casein or SPI+. Insulin resistance, steatosis, and hypercholesterolemia in the Western diet-fed rats were partially prevented by SPI+ (P < 0.05). Nuclear sterol receptor element binding protein (SREBP)-1c protein and mRNA and protein expression of enzymes involved in fatty acid synthesis were increased by feeding Western diets containing casein but not SPI+ (P < 0.05). These data suggest that activation of PPAR and LXR signaling and inhibition of SREBP-1c signaling may contribute to insulin sensitization and improved lipid homeostasis in SPI+-fed rats after consumption of diets high in fat and cholesterol.

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