The effect of weight loss on anti-Müllerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment  

Oleh:

Thomson, R.L. ; Buckley, J.D. ; Moran, L.J. ; Noakes, M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Human Reproduction vol. 24 no. 08 (Aug. 2009), page 1976-1981.
Topik: weight loss/anti-Müllerian hormone/reproductive function/menstrual cyclicity

Ketersediaan

Perpustakaan FK Nomor Panggil: H07.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND: Anti-Müllerian hormone (AMH) has been proposed as a clinical predictor of improvements in reproductive function following weight loss in overweight and obese women with polycystic ovary syndrome (PCOS). This study aimed to assess whether baseline and/or change in AMH levels with weight loss predict improvements in reproductive function in overweight and obese women with PCOS. METHODS: Fifty-two overweight and obese women with PCOS and reproductive impairment (age 29.8 ± 0.8 years, BMI 36.5 ± 0.7 kg/m2) followed a 20-week weight loss programme. AMH, weight, menstrual cyclicity and ovulatory function were assessed at baseline and post-intervention. RESULTS: Participants who responded with improvements in reproductive function (n = 26) had lower baseline AMH levels (23.5 ± 3.7 versus 32.5 ± 2.9 pmol/l; P = 0.03) and experienced greater weight loss (–11.7 ± 1.2 versus –6.4 ± 0.9 kg; P = 0.001) compared with those who did not respond (n = 26). Logistic regression analysis showed that weight loss and baseline AMH were independently related to improvements in reproductive function (P = 0.002 and P = 0.013, respectively). AMH levels did not change with weight loss in both responders and non-responders. CONCLUSIONS: In overweight and obese women with PCOS and reproductive dysfunction, a 20-week weight loss intervention resulted in improvements in reproductive function but no change in AMH levels.

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