Glycosaminoglycan and transforming growth factor ß1 changes in human plasma and urine during the menstrual cycle, in vitro fertilization treatment, and pregnancy  

Oleh:

Muro, Pierina De ; Capobianco, Giampiero ; Formato, Marilena ; Lepedda, Antonio Junior ; Cherchi, Mario ; Dessole, Salvatore

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), page 320-327.
Topik: Transforming growth factor ß1; glycosaminoglycans; urinary trypsin inhibitor; women

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To evaluate transforming growth factor ß1 (TGF-ß1) and glycosaminoglycans (GAG) changes in human plasma and urine during the menstrual cycle, IVF-ET, and pregnancy. Design : Prospective clinical study. Setting : University hospital. Patient(s) : Thirteen women with apparently normal menstrual cycle (group 1); 18 women undergoing IVF-ET (group 2); and 14 low-risk pregnant women (group 3). Intervention(s) : We assayed plasma and urine concentrations of TGF-ß1, urine content, and distribution of GAG. Blood and urine samples were collected during days 2 to 3, 12 to 13, and 23 to 24 in group 1; in group 2, samples were obtained at menstrual phase, oocyte pick-up day, and 15 days after ET; in group 3, samples were obtained during gestational weeks 10–12, 22–24, and 30–32 and 1 month after delivery. Main Outcome Measure(s) : Changes in TGF-ß1 and GAG content. Result(s) : The mean value of total urinary trypsin inhibitor/chondroitin sulfate (UTI/CS) showed a distinct peak at day 12 of the menstrual cycle in the fertile women in whom we monitored the ovulatory period. In the IVF-ET group, GAG distribution and TGF-ß1 levels showed significant differences during the cycle. We observed increased levels of plasma TGF-ß1 15 days after ET. A significant increase of total UTI/CS value with increasing gestation was detected. Conclusion(s) : Transforming growth factor ß1 and GAG levels could represent an additional tool to monitor reproductive events and could be useful, noninvasive markers of ovulation and ongoing pregnancy.

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