An increased serum progesterone-to-estradiol ratio on the day of human chorionic gonadotropin administration does not have a negative impact on clinical pregnancy rate in women with normal ovarian reserve treated with a long gonadotropin releasing hormone agonist protocol  

Oleh:

Tsung-Hsuan, Lai ; Fa-Kung, Lee ; Tseng-Kai, Lin ; Shang-Gwo, Horng

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 02 (Aug. 2009), page 508-514.
Topik: Premature luteinization; IVF; pregnancy rate; progesterone; estradiol; ovarian reserve; gonadotropin releasing hormone agonist

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To evaluate the relationship between serum P:E2 ratio on the day of hCG administration and the clinical outcomes in infertile women with normal ovarian reserve treated with a long GnRH agonist (GnRH-a) protocol. Design : Retrospective analysis of IVF-embryo transfer data. Setting : University teaching hospital. Patient(s) : One hundred thirty-nine infertile women with normal ovarian reserve, who received IVF-embryo transfer with a long GnRH-a protocol. Intervention(s) : Cycles were grouped according to whether premature luteinization (PL) appeared on the day of hCG administration. Premature luteinization was defined as a P:E2 ratio =1.2 by using receiver operator characteristic analysis. Main Outcome Measure(s) : Treatment cycle hormonal characteristics and clinical outcomes. Result(s) : The P:E2 ratio on the day of hCG administration was significantly higher in the PL (n = 41) compared with the non-PL (n = 98) group (2.4 ± 1.5 and 0.6 ± 0.3, respectively). The mean number of oocytes retrieved in the PL and non-PL groups were 4.2 ± 2.8 and 12.7 ± 6.6, respectively. However, the difference between the clinical pregnancy rates (PR) in the PL and non-PL groups was not statistically significant (29.3% vs. 34.5%). In a logistic regression analysis, the P:E2 ratio showed no statistically significant correlation with pregnancy outcome. Conclusion(s) : The increased serum P:E2 ratio on the day of hCG administration, as an indicator of PL, has a poor predictive value on IVF outcomes in infertile women with normal ovarian reserve treated with a long GnRH-a protocol.

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